Search Result

Results for "

moderate activity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (4) Adrenergic Receptor (3) Amyloid-β (1) Androgen Receptor (1) Antibiotic (6) Apoptosis (7) Bacterial (21) Beta-lactamase (1) Beta-secretase (1) Calcium Channel (2) CCR (1) CDK (1) Cholinesterase (ChE) (5) COX (3) Cytochrome P450 (2) DNA/RNA Synthesis (5) Dopamine Receptor (2) EGFR (1) Elastase (1) Endogenous Metabolite (2) Enterovirus (2) ERK (1) FAK (1) Free Fatty Acid Receptor (1) Fungal (9) Glucosidase (3) HBV (1) HDAC (2) Histone Acetyltransferase (1) Histone Demethylase (1) HIV (2) HIV Protease (1) Interleukin Related (1) Isotope-Labeled Compounds (3) JAK (1) Kinesin (1) LPL Receptor (2) mAChR (3) MEK (1) Microtubule/Tubulin (1) MMP (1) Monoamine Oxidase (1) NADPH Oxidase (1) NAMPT (1) NF-κB (1) Orthopoxvirus (1) P-glycoprotein (2) Parasite (4) Phosphatase (1) Phosphodiesterase (PDE) (4) PI3K (1) Polo-like Kinase (PLK) (1) Potassium Channel (1) PPAR (3) Progesterone Receptor (1) PROTACs (1) Raf (1) Reactive Oxygen Species (1) RSV (2) SARS-CoV (1) Sigma Receptor (2) STAT (2) Tau Protein (1) Thymidylate Synthase (4) Tyrosinase (1) Wnt (1)
By Research Areas:	Cancer (35) Endocrinology (4) Infection (43) Inflammation/Immunology (13) Metabolic Disease (7) Neurological Disease (25)

By Targets:

5-HT Receptor (4)

Adrenergic Receptor (3)

Amyloid-β (1)

Androgen Receptor (1)

Antibiotic (6)

Apoptosis (7)

Bacterial (21)

Beta-lactamase (1)

Beta-secretase (1)

Calcium Channel (2)

CCR (1)

CDK (1)

Cholinesterase (ChE) (5)

COX (3)

Cytochrome P450 (2)

DNA/RNA Synthesis (5)

Dopamine Receptor (2)

EGFR (1)

Elastase (1)

Endogenous Metabolite (2)

Enterovirus (2)

ERK (1)

FAK (1)

Free Fatty Acid Receptor (1)

Fungal (9)

Glucosidase (3)

HBV (1)

HDAC (2)

Histone Acetyltransferase (1)

Histone Demethylase (1)

HIV (2)

HIV Protease (1)

Interleukin Related (1)

Isotope-Labeled Compounds (3)

JAK (1)

Kinesin (1)

LPL Receptor (2)

mAChR (3)

MEK (1)

Microtubule/Tubulin (1)

MMP (1)

Monoamine Oxidase (1)

NADPH Oxidase (1)

NAMPT (1)

NF-κB (1)

Orthopoxvirus (1)

P-glycoprotein (2)

Parasite (4)

Phosphatase (1)

Phosphodiesterase (PDE) (4)

PI3K (1)

Polo-like Kinase (PLK) (1)

Potassium Channel (1)

PPAR (3)

Progesterone Receptor (1)

PROTACs (1)

Raf (1)

Reactive Oxygen Species (1)

RSV (2)

SARS-CoV (1)

Sigma Receptor (2)

STAT (2)

Tau Protein (1)

Thymidylate Synthase (4)

Tyrosinase (1)

Wnt (1)

By Research Areas:

Cancer (35)

Endocrinology (4)

Infection (43)

Inflammation/Immunology (13)

Metabolic Disease (7)

Neurological Disease (25)

121

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N10420

Hinokinin 1 Publications Verification (-)-Hinokinin	HIV Protease	Infection
Hinokinin (Compound 1) is a compound isolated from the stems of Hypoestes aristate. Hinokinin exhibits moderate activity of HIV-1 protease enzyme .

HY-145112

AChE-IN-3

Cholinesterase (ChE) Neurological Disease

AChE-IN-3 shows moderate inhibitory activity against AChE and strong NO inhibitory activity with an EC₅₀ of 0.57 μM.
HY-B2044

Bromopropylate

Bromopropylate is a pesticide with moderate anti-androgenic activities .

AChE-IN-3	Cholinesterase (ChE)	Neurological Disease
AChE-IN-3 shows moderate inhibitory activity against AChE and strong NO inhibitory activity with an EC₅₀ of 0.57 μM.

Bromopropylate
Bromopropylate is a pesticide with moderate anti-androgenic activities .

HY-N8764

Decaffeoylacteoside Decaffeoylverbascoside; Verbasoside	Monoamine Oxidase Cholinesterase (ChE)	Neurological Disease Cancer
Decaffeoylacteoside is an inhibitor of AChE/BChE/LOX with moderate activity .

HY-N8167

Plantanone B Kaempferol 3-O-rhamnosylgentiobioside	COX	Inflammation/Immunology
Plantanone B is a moderate antioxidant-agent with an IC₅₀ of 169.8±5.2 μM. Plantanone B shows significant ovine COX-1 and moderate COX-2 inhibitory activities. Plantanone B has the potential for inflammation-related diseases research .

HY-77195

Poloxime

Polo-like Kinase (PLK) Cancer

Poloxime, a hydrolysis product of poloxin, is a non-ATP-competitive Plk1 inhibitor, with moderate Plk1 inhibitory activity.
HY-N2395

Chrysophanol 8-O-glucoside

1 Publications Verification

Elastase Cancer

Chrysophanol 8-O-glucoside, from the roots of Rumex acetosa, shows moderate elastase inhibition activity .
HY-P5698

Cyclopetide 1

Bacterial Infection

Cyclopetide 1 (Compound 1) is an antimicrobial peptide with moderate activity against B. subtilis, with a MIC of 25 μg/mL .
HY-P5699

Cyclopetide 2

Bacterial Infection

Cyclopetide 2 (Compound 2) is an antimicrobial peptide with moderate activity against B. subtilis, with a MIC of 50 μg/mL .

Poloxime	Polo-like Kinase (PLK)	Cancer
Poloxime, a hydrolysis product of poloxin, is a non-ATP-competitive Plk1 inhibitor, with moderate Plk1 inhibitory activity.

Chrysophanol 8-O-glucoside 1 Publications Verification	Elastase	Cancer
Chrysophanol 8-O-glucoside, from the roots of Rumex acetosa, shows moderate elastase inhibition activity .

Cyclopetide 1	Bacterial	Infection
Cyclopetide 1 (Compound 1) is an antimicrobial peptide with moderate activity against B. subtilis, with a MIC of 25 μg/mL .

Cyclopetide 2	Bacterial	Infection
Cyclopetide 2 (Compound 2) is an antimicrobial peptide with moderate activity against B. subtilis, with a MIC of 50 μg/mL .

HY-121069

Elubiol Dichlorophenyl imidazoldioxolan	Others	Others
Elubiol (Dichlorophenyl imidazoldioxolan) has moderate sebum-inhibiting activity and can be used in the treatment of oily skin or dandruff .

HY-N3789

Dunnianol	Bacterial	Infection
Dunnianol is a natural sesqui-neoligan with moderate antibacterial activity. Dunnianol inhibits *Staphylococcus aureus* and *methicillin-resistant Staphylococcus aureus* (MRSA)**.

HY-146162

Colletotrichalactones A

Others Cancer

Colletotrichalactones A is a polyketide that display moderate-to-potent cytotoxic activities against MCF7 cells with an IC₅₀ of 35.06 µM .

Colletotrichalactones A	Others	Cancer
Colletotrichalactones A is a polyketide that display moderate-to-potent cytotoxic activities against MCF7 cells with an IC₅₀ of 35.06 µM .

HY-N10114

Hyperectumine	Others	Inflammation/Immunology
Hyperectumine exhibits moderate anti-inflammatory activity via suppression of LPS-activated inflammatory mediators in RAW 264.7 macrophage cells.

HY-N10912

Shizukanolide	Others	Infection
Shizukanolide, a sesquiterpene lactone, can be isolated from Chloranthus japonicus (Chloranthaceae). The dehydro-compound of Shizukanolide, shows moderate antifungal activity .

HY-N11949

Interiorin

HIV Infection

Interiorin can be isolated from Kadsura heteroclita and has moderate anti-HIV activity with an EC50 value of 1.6 lg/mL .

Interiorin	HIV	Infection
Interiorin can be isolated from Kadsura heteroclita and has moderate anti-HIV activity with an EC50 value of 1.6 lg/mL .

HY-156359

Tuberculosis inhibitor 10	Others	Others
Tuberculosis inhibitor 10 shows moderate inhibitory effect on the enzymatic activity of MSMEG_6649. Tuberculosis inhibitor 10 enhances the inhibitory activity of PAS against mycobacteria .

HY-N11655

Antioxidant agent-10

Others Others

Antioxidant agent-10 (Compound 3) is an antioxidant agent that exhibits moderate DPPH scavenging activity with an EC₅₀ of 33.2 μg/mL .

Antioxidant agent-10	Others	Others
Antioxidant agent-10 (Compound 3) is an antioxidant agent that exhibits moderate DPPH scavenging activity with an EC₅₀ of 33.2 μg/mL .

HY-N12538

trans-Cinnamic anhydride	Parasite	Infection
trans-Cinnamic anhydride is a Parasite inhibitor tnat can be isolated from Cinnamomum zeylanicum and exhibits moderate activity against Plasmodium falciparum .

HY-121020

Arcapillin	Phosphatase	Neurological Disease
Arcapillin is a flavonoid that can be isolated from Artemisia capillaris Thunb. Arcapillin has antispasmodic activity. Arcapillin also has moderate PTP1B inhibitory activity .

HY-N4151

Chrysophanein	Others	Cancer
Chrysophanein is a chrysophanol glycoside from leaves and roots of Aloe hijazensis. Chrysophanein shows a moderate cytotoxic activity against several carcinoma cells lines .

HY-N7990

Scheffoleoside A	Others	Neurological Disease
Scheffoleoside A is a neuroprotective agent can be derived from Centella asiatica. Scheffoleoside A exhibits moderate activity in inhibiting 6-OHDA-induced cytotoxicity .

HY-N11965

4'-Methoxyisoagarotetrol	Phosphodiesterase (PDE)	Inflammation/Immunology
4'-Methoxyisoagarotetrol is chromone derivative and shows moderate PDE?3A inhibitory activity (IC₅₀=54 μM) .

HY-105634

Nomegestrol	Progesterone Receptor	Endocrinology Cancer
Nomegestrol is a potent and orally available progestin, acts as a selective full progesterone receptor agonist, with a K_d of 5.44 nM for rat uterine progesterone receptor, and has moderate antiandrogenic activity and strong antiestrogenic activity.

HY-N8355

Beauveriolide I	Endogenous Metabolite	Infection
Beauveriolide I is the metabolite of Entomopathogenic Fungi Beauveria sp.. Beauveriolide I (1) exhibits moderate insecticidal activities against Spodoptera litura and Callosobruchus chinensis .

HY-N10160

Daturadiol

12-Oleanene-3,6-diol
Others Cancer

Daturadiol (12-Oleanene-3,6-diol), a triterpenoid, displays moderate cytotoxic activity against human cancer cell lines .

Daturadiol 12-Oleanene-3,6-diol	Others	Cancer
Daturadiol (12-Oleanene-3,6-diol), a triterpenoid, displays moderate cytotoxic activity against human cancer cell lines .

HY-B2056

Triforine CELA W 524
Triforine (CELA W 524), a systemic fungicide, was shown to display a moderate to distinct fungitoxic activity in vitro towards several pathogenic and non-pathogenic fungi .

HY-N8443

Isoaltenuene	Bacterial	Infection
Isoaltenuene is an anti-bacterial agent with moderate activity against Staphylococcus aureus. Isoaltenuene can be isolated from fungus Alternaria alternate cib-137 .

HY-N9447

Norbergenin 1 Publications Verification	Reactive Oxygen Species	Neurological Disease
Norbergenin, the O-demethyl derivative of bergenin, shows moderate antioxidant activity (IC₅₀ 13 μM in DPPH radical scavenging; 32 μM in superoxide anion scavenging) .

HY-N1077

Vomifoliol
Vomifoliol, a compound related to abscisie acid (ABA), has a modified 2,4-pentadiene side chain and has activity equal to that displayed by ABA. Vomifoliol exhibits antiacetylcholinesterase activity and displays moderate antileishmanial activity .

HY-B1299A

Cephalosporin C zinc salt	Bacterial Orthopoxvirus Antibiotic	Infection Inflammation/Immunology
Cephalosporin C zinc salt is a potent inhibitor of SAMHD1 with an IC₅₀ of 1.1 μM . Cephalosporin C zinc salt also has moderate anti-orthopoxvirus activity .

HY-N1859

3'-O-Methylorobol

3'-O-Methylorobol, an antioxidant flavonoid, exhibits moderate antioxidant activity in the 2,2-diphenyl-1-picrylhydrazyl free radical scavenging assay .

3'-O-Methylorobol
3'-O-Methylorobol, an antioxidant flavonoid, exhibits moderate antioxidant activity in the 2,2-diphenyl-1-picrylhydrazyl free radical scavenging assay .

HY-N2198

Podocarpusflavone A
Podocarpusflavone A is a DNA topoisomerase I inhibitor. Podocarpusflavone A has moderated anti-proliferative activity and induces cell apoptosis in MCF-7. Podocarpusflavone A is developing anti-tumor agents .

HY-152091

Antiproliferative agent-18	Fungal	Infection Cancer
Antiproliferative agent-18 (Compound 5k) is an anti-proliferative agent. Antiproliferative agent-18 also displays moderate anti-bacterial and anti-fungi activity .

HY-N6005

Methyl caffeate	Bacterial	Infection Cancer
Methyl caffeate, an antimicrobial agent, shows moderate antimicrobial and prominent antimycobacterial activities. Methyl caffeate also exhibits α-glucosidase inhibition activity, oxidative stress inhibiting activity, anti-platelet activity, antiproliferative activity in cervix adenocarcinoma and anticancer activity in lung and leukmia cell lines .

HY-W019829

Polyphyllin C	Tyrosinase Parasite	Infection
Polyphyllin C (compound 2) is a spirostanol saponin. Polyphyllin C exhibits mild (IC₅₀=36.87 µM) activities against the tyrosinase and moderate (IC₅₀=1.59 µg/mL) antileishmanial activities .

HY-19937

Saroglitazar 4 Publications Verification	PPAR	Metabolic Disease
Saroglitazar is a novel peroxisome proliferator-activated receptor (PPAR) agonist with predominant PPARα and moderate PPARγ activity with EC₅₀ values of 0.65 pM and 3 nM in HepG2 cells, respectively.

HY-109706

(Rac)-CPI-098	Bacterial Fungal	Infection
(Rac)-CPI-098 shows antibacterial activity. (Rac)-CPI-098 exhibits superior anti-fungal activity against Monascus ruber, better activity against Aspergillus fumigates, good activity against Aspergillus niger and Aspergillus parasites and moderate activity against Candida albicans .

HY-101298

Paprotrain 1 Publications Verification	Kinesin	Neurological Disease
Paprotrain is a cell-permeable inhibitor of the kinesin MKLP-2, inhibits the ATPase activity of MKLP-2 with an IC₅₀ of 1.35 μM and a K_i of 3.36 μM and shows a moderate inhibition activity on DYRK1A with an IC₅₀ of 5.5 μM.

HY-19937A

Saroglitazar magnesium 4 Publications Verification	PPAR	Metabolic Disease
Saroglitazar magnesium is a novel peroxisome proliferator-activated receptor (PPAR) agonist with predominant PPARα and moderate PPARγ activity with EC₅₀ values of 0.65 pM and 3 nM in HepG2 cells, respectively.

HY-126237

Acetyllovastatin	Fungal	Infection
Acetyllovastatin, a acetate of Lovastatin, presentes a moderate inhibitory effect against the enzyme acetylcholinesterase with an IC₅₀ of 79 μg/mL. Lovastatin has been found to display antifungal activity, and suppresses proliferation of a number of transformed cell lines .

HY-N11501

7-epi-Isogarcinol	STAT Apoptosis	Cancer
7-epi-Isogarcinol is a polycyclic polyprenylated acylphloroglucinol (PPAP), with moderate antiproliferative activity. 7-epi-Isogarcinol blocks STAT3 signaling pathway, to induce apoptosis and inhibit cell migration .

HY-N12337

Asperazine (+)-Asperazine	Others	Cancer
Asperazine (Compound 5) is an alkaloid derived from the fungus Penicillium oxalicum. Asperazine shows only moderate activity against HepG2 and CaSki cell lines (IC₅₀>50 μM) .

HY-N12635

Levinoid C	Others	Neurological Disease
Levinoid C is a Cytochrome P450-modified bacterial terpenoid. Levinoid C shows moderate neuroprotective activity against glutamate-induced excitotoxicity cell model with an EC₅₀ of 21 μM .

HY-155410

HPSE1-IN-1	Endogenous Metabolite	Metabolic Disease
HPSE1-IN-1 (compound 16) is a selective inhibitor of Heparanase-1 (HPSE1) with moderate inhibitory activity against exo-β-d-glucuronidase (GUSβ) and glucocerebrosidase (GBA) .

HY-N10267

Carviolin	Fungal	Infection
Carviolin is a compound isolated from the mycelia of the ascomycete Neobulgaria pura. Carviolin inhibits the formation of appressoria in germinating conidia of Magnaporthe grisea on inductive (hydrophobic) surface. Carviolin exhibits moderate cytotoxic, but no antifungal, antibacterial, or phytotoxic activities .

HY-N0495

Aloenin Aloenin A	Beta-secretase	Neurological Disease
Aloenin (Aloenin A) is a kind of natural product, has effective clearing and free radical activity, and has moderate inhibitory activity on β-secretion (BACE) (IC50=14.95 μg/mL). Aloenin suppresses peritoneal hypertrophy in large rats and suppresses its release.

HY-W008864

Lactose octaacetate β-Octaacetyllactose	Antibiotic Fungal	Infection
Lactose octaacetate shows mild to moderate antifungal activity against some fungi, but it has low or no activity against bacteria and yeast. Lactose octaacetate shows low cytotoxicity to MDBK cells, Hep-2 and MDCK cells. Lactose octaacetate has antiviral activity against PV-1 .

HY-14273

Isavuconazole 3 Publications Verification BAL-4815; RO-0094815	Fungal Cytochrome P450 Antibiotic	Infection
Isavuconazole (BAL-4815) is a triazole proagent with antifungal activity against yeasts, molds, and dimorphic fungi. Isavuconazole inhibits ergosterol biosynthesis and results in the disruption of fungal membrane structure and function. Isavuconazole is a moderate inhibitor of CYP3A4.

HY-146023

Antifungal agent 27	Bacterial Fungal	Infection
Antifungal agent 27 (compound 7) is a antifungal agent. Antifungal agent 27 shows moderate antibacterial and weak antifungal activities against MRSA and C. albicans SS5314, with MIC values of 8 and 32 μg/mL, respectively .

HY-N5045

Jionoside A1	Others	Inflammation/Immunology
Jionoside A1 isolated from Radix Rehmanniae Praeparata displays dose dependent immune-enhancement activity and possesses moderate protective activities on H₂O₂-treated SH-SY5Y cells .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N10420

Hinokinin 1 Publications Verification (-)-Hinokinin	Infection Classification of Application Fields Acanthaceae Source classification Lignans Phenylpropanoids Plants Hypoestes aristata (Vahl) Sol. ex Roem. & Schult. Disease Research Fields	HIV Protease
Hinokinin (Compound 1) is a compound isolated from the stems of Hypoestes aristate. Hinokinin exhibits moderate activity of HIV-1 protease enzyme .

HY-N2395

Chrysophanol 8-O-glucoside 1 Publications Verification	Quinones Monophenols Classification of Application Fields Rheum palmatum L. Anthraquinones Polygonaceae Source classification Phenols Plants Disease Research Fields Cancer	Elastase
Chrysophanol 8-O-glucoside, from the roots of Rumex acetosa, shows moderate elastase inhibition activity .

HY-N8764

Decaffeoylacteoside Decaffeoylverbascoside; Verbasoside	Structural Classification Labiatae Source classification Phenols Polyphenols Plants Ambrosia hispida	Monoamine Oxidase Cholinesterase (ChE)
Decaffeoylacteoside is an inhibitor of AChE/BChE/LOX with moderate activity .

HY-N8167

Plantanone B Kaempferol 3-O-rhamnosylgentiobioside	Flavonols Flavonoids Classification of Application Fields Source classification Camellia oleifera Abel. Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology Theaceae	COX
Plantanone B is a moderate antioxidant-agent with an IC₅₀ of 169.8±5.2 μM. Plantanone B shows significant ovine COX-1 and moderate COX-2 inhibitory activities. Plantanone B has the potential for inflammation-related diseases research .

HY-P5698

Cyclopetide 1	Structural Classification Animals Ketones, Aldehydes, Acids Source classification	Bacterial
Cyclopetide 1 (Compound 1) is an antimicrobial peptide with moderate activity against B. subtilis, with a MIC of 25 μg/mL .

HY-P5699

Cyclopetide 2	Structural Classification Animals Ketones, Aldehydes, Acids Source classification	Bacterial
Cyclopetide 2 (Compound 2) is an antimicrobial peptide with moderate activity against B. subtilis, with a MIC of 50 μg/mL .

HY-N3789

Dunnianol	Infection Classification of Application Fields Source classification Lignans Illicium dunnianum Tutch. Phenols Polyphenols Illiciaceae Phenylpropanoids Plants Disease Research Fields	Bacterial
Dunnianol is a natural sesqui-neoligan with moderate antibacterial activity. Dunnianol inhibits *Staphylococcus aureus* and *methicillin-resistant Staphylococcus aureus* (MRSA)**.

HY-N10114

Hyperectumine	Alkaloids Classification of Application Fields Source classification Hypecoum erectum L. Plants Isoquinoline Alkaloids Disease Research Fields Inflammation/Immunology Papaveraceae	Others
Hyperectumine exhibits moderate anti-inflammatory activity via suppression of LPS-activated inflammatory mediators in RAW 264.7 macrophage cells.

HY-N10912

Shizukanolide	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Lauraceae Lindera aggregata (Sims) Kosterm.	Others
Shizukanolide, a sesquiterpene lactone, can be isolated from Chloranthus japonicus (Chloranthaceae). The dehydro-compound of Shizukanolide, shows moderate antifungal activity .

HY-N11949

Interiorin	Structural Classification Kadsura heteroclita (Roxb.) Craib Source classification Lignans Phenylpropanoids Plants Schisandraceae	HIV
Interiorin can be isolated from Kadsura heteroclita and has moderate anti-HIV activity with an EC50 value of 1.6 lg/mL .

HY-N11655

Antioxidant agent-10	Structural Classification Flavonoids Flavones Leguminosae Source classification Plants Cajanus cajan (L.) Millsp.	Others
Antioxidant agent-10 (Compound 3) is an antioxidant agent that exhibits moderate DPPH scavenging activity with an EC₅₀ of 33.2 μg/mL .

HY-N12538

trans-Cinnamic anhydride	Structural Classification Natural Products Source classification Cinnamomum verum J. Presl Plants Lauraceae	Parasite
trans-Cinnamic anhydride is a Parasite inhibitor tnat can be isolated from Cinnamomum zeylanicum and exhibits moderate activity against Plasmodium falciparum .

HY-121020

Arcapillin	Structural Classification Flavonoids Flavones Source classification Plants Compositae Artemisia capillaris Thunb.	Phosphatase
Arcapillin is a flavonoid that can be isolated from Artemisia capillaris Thunb. Arcapillin has antispasmodic activity. Arcapillin also has moderate PTP1B inhibitory activity .

HY-N4151

Chrysophanein	Quinones Monophenols Classification of Application Fields Rheum palmatum L. Anthraquinones Polygonaceae Source classification Phenols Plants Disease Research Fields Cancer	Others
Chrysophanein is a chrysophanol glycoside from leaves and roots of Aloe hijazensis. Chrysophanein shows a moderate cytotoxic activity against several carcinoma cells lines .

HY-N7990

Scheffoleoside A	Structural Classification Polysaccharides Source classification Plants Umbelliferae Vitex trifolia L. Saccharides	Others
Scheffoleoside A is a neuroprotective agent can be derived from Centella asiatica. Scheffoleoside A exhibits moderate activity in inhibiting 6-OHDA-induced cytotoxicity .

HY-N11965

4'-Methoxyisoagarotetrol	Structural Classification Natural Products Thymelaeaceae Source classification Plants Aquilaria sinensis (Lour.) Spreng.	Phosphodiesterase (PDE)
4'-Methoxyisoagarotetrol is chromone derivative and shows moderate PDE?3A inhibitory activity (IC₅₀=54 μM) .

HY-N8355

Beauveriolide I	Infection Alkaloids Structural Classification Microorganisms Classification of Application Fields Source classification Disease Research Fields	Endogenous Metabolite
Beauveriolide I is the metabolite of Entomopathogenic Fungi Beauveria sp.. Beauveriolide I (1) exhibits moderate insecticidal activities against Spodoptera litura and Callosobruchus chinensis .

HY-N8443

Isoaltenuene	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source classification	Bacterial
Isoaltenuene is an anti-bacterial agent with moderate activity against Staphylococcus aureus. Isoaltenuene can be isolated from fungus Alternaria alternate cib-137 .

HY-N9447

Norbergenin 1 Publications Verification	Natural Products other families Source classification Phenols Polyphenols Plants	Reactive Oxygen Species
Norbergenin, the O-demethyl derivative of bergenin, shows moderate antioxidant activity (IC₅₀ 13 μM in DPPH radical scavenging; 32 μM in superoxide anion scavenging) .

HY-N6005

Methyl caffeate	Infection Classification of Application Fields Simple Phenylpropanols Source classification Phenols Polyphenols Solanum torvum Swartz Phenylpropanoids Plants Solanaceae Disease Research Fields	Bacterial
Methyl caffeate, an antimicrobial agent, shows moderate antimicrobial and prominent antimycobacterial activities. Methyl caffeate also exhibits α-glucosidase inhibition activity, oxidative stress inhibiting activity, anti-platelet activity, antiproliferative activity in cervix adenocarcinoma and anticancer activity in lung and leukmia cell lines .

HY-W019829

Polyphyllin C	Infection other families Classification of Application Fields Source classification Plants Disease Research Fields Steroids	Tyrosinase Parasite
Polyphyllin C (compound 2) is a spirostanol saponin. Polyphyllin C exhibits mild (IC₅₀=36.87 µM) activities against the tyrosinase and moderate (IC₅₀=1.59 µg/mL) antileishmanial activities .

HY-N11501

7-epi-Isogarcinol	Structural Classification Natural Products Garcinia xanthochymus Hook. f. ex T. Anders. Source classification Guttiferae Plants	STAT Apoptosis
7-epi-Isogarcinol is a polycyclic polyprenylated acylphloroglucinol (PPAP), with moderate antiproliferative activity. 7-epi-Isogarcinol blocks STAT3 signaling pathway, to induce apoptosis and inhibit cell migration .

HY-N12337

Asperazine (+)-Asperazine	Structural Classification Alkaloids Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite Indole Alkaloids	Others
Asperazine (Compound 5) is an alkaloid derived from the fungus Penicillium oxalicum. Asperazine shows only moderate activity against HepG2 and CaSki cell lines (IC₅₀>50 μM) .

HY-N12635

Levinoid C	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source classification	Others
Levinoid C is a Cytochrome P450-modified bacterial terpenoid. Levinoid C shows moderate neuroprotective activity against glutamate-induced excitotoxicity cell model with an EC₅₀ of 21 μM .

HY-155410

HPSE1-IN-1	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
HPSE1-IN-1 (compound 16) is a selective inhibitor of Heparanase-1 (HPSE1) with moderate inhibitory activity against exo-β-d-glucuronidase (GUSβ) and glucocerebrosidase (GBA) .

HY-N10267

Carviolin	Infection Quinones Structural Classification Microorganisms Classification of Application Fields Anthraquinones Source classification Phenols Polyphenols Disease Research Fields	Fungal
Carviolin is a compound isolated from the mycelia of the ascomycete Neobulgaria pura. Carviolin inhibits the formation of appressoria in germinating conidia of Magnaporthe grisea on inductive (hydrophobic) surface. Carviolin exhibits moderate cytotoxic, but no antifungal, antibacterial, or phytotoxic activities .

HY-N0495

Aloenin Aloenin A	Structural Classification Liliaceae Source classification Phenols Aloe vera (L.) Burm. f. Plants	Beta-secretase
Aloenin (Aloenin A) is a kind of natural product, has effective clearing and free radical activity, and has moderate inhibitory activity on β-secretion (BACE) (IC50=14.95 μg/mL). Aloenin suppresses peritoneal hypertrophy in large rats and suppresses its release.

HY-N5045

Jionoside A1	Classification of Application Fields Simple Phenylpropanols Source classification Phenols Polyphenols Scrophulariaceae Phenylpropanoids Plants Rehmannia glutinosa (Gaert.) Libosch. ex Fisch. et Mey Disease Research Fields Inflammation/Immunology	Others
Jionoside A1 isolated from Radix Rehmanniae Praeparata displays dose dependent immune-enhancement activity and possesses moderate protective activities on H₂O₂-treated SH-SY5Y cells .

HY-N3837

Epitaraxerol Isotaraxerol; 3α-Taraxerol	Triterpenes Structural Classification Excoecaria agallocha L. Terpenoids Source classification Euphorbiaceae Plants	Others
Epitaraxerol (compound 6) is a natural product isolated from the leaves of E. neriifolia. Epitaraxerol shows moderate antifungal activity against C. albicans and low antimicrobial activity against T. mentagrophytes, A. niger, S. aureus, E. coli, P. aeruginosa, and B. subtilis* .*

HY-N6007

Chrysosplenol D	Infection Flavonols Flavonoids other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology	Apoptosis
Chrysosplenol D is a methoxy flavonoid that induces ERK1/2-mediated apoptosis in triple negative human breast cancer cells. Chrysosplenol D also exhibits anti-inflammatory and moderate antitrypanosomal activities .

HY-113632

Debromohymenialdisine 10Z-Debromohymenialdisine	Structural Classification Natural Products Classification of Application Fields Marine natural products Sponge Disease Research Fields Cancer	Raf MEK
Debromohymenialdisine (10Z-Debromohymenialdisine) is a pyrrole alkaloid. Debromohymenialdisine has moderate inhibitory activity with an IC₅₀ value of 881 nM in the initial Raf/MEK-1/MAPK signaling cascade assay. Debromohymenialdisine can be used for the research of proliferation and differentiation .

HY-N0720

Neobavaisoflavone Maximum Cited Publications 10 Publications Verification	Flavonoids Classification of Application Fields Leguminosae Source classification Phenols Polyphenols Psoralea corylifolia L. Plants Disease Research Fields Isoflavones Cancer	Apoptosis DNA/RNA Synthesis
Neobavaisoflavone, a flavonoid, is isolated from the seeds of Psoralea corylifolia. Neobavaisoflavone exhibits anti-inflammatory, anti-cancer and anti-oxidation activities. Neobavaisoflavone inhibits DNA polymerase at moderate to high concentrations. Neobavaisoflavone also inhibits platelet aggregation .

HY-N10441

3β-Hydroxy-hop-22(29)-ene	Cnidoscolus spinosus Lundell Triterpenes Terpenoids Source classification Euphorbiaceae Plants	Parasite
3β-Hydroxy-hop-22(29)-ene (compound 3) is a potent antiparasitic agent. 3β-Hydroxy-hop-22(29)-ene shows moderate activity against Trypanosoma cruzi and Leishmania mexicana .

HY-N3239

Mulberrofuran G	Structural Classification Source classification Phenols Polyphenols Plants Moraceae Morus alba Linn.	NADPH Oxidase HBV
Mulberrofuran G protects ischemic injury-induced cell death via inhibition of NOX4-mediated ROS generation and ER stress . Mulberrofuran G shows moderate inhibiting activity of hepatitis B virus (HBV) DNA replication with IC₅₀ of 3.99 μM .

HY-N12072

3'-Methoxy-3,5,4'-trihydroxyflavone-7-neohesperidoside	Structural Classification Flavonols Flavonoids Cleome droserifolia (Forssk.) Delile Source classification Plants Capparidaceae	Others
3'-Methoxy-3,5,4'-trihydroxyflavone-7-neohesperidoside is a flavonoid that can be isolated from Cleome droserifolia. 3'-Methoxy-3,5,4'-trihydroxyflavone-7-neohesperidoside has moderate hepatoprotective activity ..

HY-155704

Lyciumamide A	Structural Classification Lycium barbarum L. Source classification Phenols Polyphenols Plants Solanaceae	Others
DPP-IV-IN-5 is isolated from the fruits of Lycium barbarum. DPP-IV-IN-5 exerts moderate agonistic activities for peroxisome proliferator-activated receptor (PPARγ) with EC₅₀ values of 10.09 - 44.26 μM and also presents inhibitory activity on dipeptidyl peptidase-4 (DPPIV) with an IC₅₀ value of 47.13 μM .

HY-N1839

3-Hydroxybakuchiol	Structural Classification Leguminosae Source classification Phenols Polyphenols Plants Otholobium mexicanum (L.f.) J.W.Grimes	Apoptosis Glucosidase
3-Hydroxybakuchiol can be isolated from Otholobium mexicanum J. W. Grimes. 3-Hydroxybakuchiol is an electron transport chain (ETC) inhibitor. 3-Hydroxybakuchiol has antitumor activity, and induces tumor cell apoptosis. 3-Hydroxybakuchiol also has moderate inhibitory activity against α-glucosidase (IC₅₀: 345 μM) .

HY-N11928

Changnanic acid	Structural Classification Kadsura heteroclita (Roxb.) Craib Ketones, Aldehydes, Acids Source classification Plants Schisandraceae	Others
Changnanic acid (schisandrin) is a triterpene compound with potential anti-tumor effects. Changnanic acid exhibits moderate cytotoxic activity against human tumor cell lines Bel-7402, MCF-7 and HL-60, with IC₅₀s of 100 μM, 100 μM and 50.51 μM respectively .

HY-N3497

Isochamaejasmin	Structural Classification Flavonoids Thymelaeaceae Stellera chamaejasme Linn. Plants Other Flavonoids	NF-κB DNA/RNA Synthesis Parasite Apoptosis
Isochamaejasmin is a biflavonoid with anti-cancer, antiplasmodial and insecticidal activities. Isochamaejasmin displays a potent NF-κB (NF-κB) activation activity. Isochamaejasmin could cause DNA damage and induce apoptosis via the mitochondrial pathway in AW1 cells . Isochamaejasmin also has a moderate antiplasmodial activity (IC₅₀ of 7.3 μM for *P. falciparum*) and relatively low cytotoxicity (CC₅₀ of 29.0 μM) .

HY-N2949

Bonducellpin D	Other Terpenoids Infection Caesalpinia minax Hance Classification of Application Fields Leguminosae Terpenoids Source classification Plants Disease Research Fields	SARS-CoV
Bonducellpin D is a furanoditerpenoid lactone isolated from Caesalpinia minax. Bonducellpin D exhibits broad-spectrum inhibition potential against SARS-CoV M ^pro and MERS-CoV M ^pro, with an K_i of 467.11 and 284.86 nM, respectively. Bonducellpin D also exhibits moderate anti-cancer activity in vitro .

HY-126535

Magnoloside B	Structural Classification Magnolia officinalis. Rehd. et Wils. Source classification Magnoliaceae Phenols Polyphenols Plants	Glucosidase
Magnoloside B is an α-glucosidase inhibitor (IC₅₀=0.69 mM), which can be obtained from Magnolia officinalis stem bark. Magnoloside B shows moderate inhibitory activity against MGC-803 and HepG2 cells. Magnoloside B has the potential to study cancer and diabetes .

HY-N9505

Schisanlactone E Kadsulactone acid	Triterpenes Structural Classification Kadsura heteroclita (Roxb.) Craib Terpenoids Source classification Plants Schisandraceae	Others
Schisanlactone E is a triterpenoids that can be isolated from Kadsura heteroclita. Schisanlactone E exhibits moderate cytotoxic activity against Bel-7402, BGC-823, MCF-7 and HL-60 cell line with IC₅₀s of 68.33, 100, >100, 73.37 μM,respectively .

HY-N7652

Terminolic acid	Triterpenes other families Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Inflammation/Immunology	Bacterial
Terminolic acid is a pentacyclic triterpenoid glucoside isolated from Combretum racemosum. Terminolic acid can inhibit the pro-inflammatory cytokines by binding to receptor active site of IL-1β and IL-6, and enhance anti-inflammatory cytokines by binding to IL-4 receptor binding sites. Terminolic acid also exhibits moderate antibacterial activity .

HY-N10440

3-Oxo-hop-22(29)-ene	Cnidoscolus spinosus Lundell Triterpenes Terpenoids Source classification Euphorbiaceae Plants	Glucosidase
3-Oxo-hop-22(29)-ene is a yeast α-glucosidase inhibitor. 3-Oxo-hop-22(29)-ene shows a moderate effect on the viability of T. cruzi and L. mexicana. 3-Oxo-hop-22(29)-ene shows marginal activity of anti-inflammatory .

HY-N6846

10-Isobutyryloxy-8,9-epoxythymol isobutyrate	Infection Natural Products Classification of Application Fields Dalbergia velutina Benth. Source classification Plants Compositae Disease Research Fields	Bacterial
10-Isobutyryloxy-8,9-epoxythymol isobutyrate is a major constituent of Inula helenium and Inula royleana root cultures. 10-Isobutyryloxy-8,9-epoxythymol isobutyrate shows moderate antimicrobial activity against Staphylococcus aureus FDA 209 P, Staphylococcus aureus, Enterococcus faecalis, Candida albicans and Pseudomonas aeruginosa with MICs of 50, 250, 250, 250, and 1000 μg/mL, respectively .

Cat. No.	Product Name	Chemical Structure

HY-W754151

N-Desmethyl apalutamide-d4

N-Desmethyl apalutamide-d₄ is the deuterium-labeled N-Desmethyl-Apalutamide (HY-135331). N-Desmethyl Apalutamide is an active metabolite of Apalutamide. N-Desmethyl Apalutamide is a less potent antagonist of the androgen receptor and is responsible for one-third of the activity of Apalutamide. The formation of N-Desmethyl Apalutamide mediated predominantly by CYP2C8 and CYP3A4. N-Desmethyl Apalutamide is moderate to strong CYP3A4 and CYP2B6 inducer and has an excellent plasma-proteins bound concentration .

HY-B1396S

Nefazodone-d6 hydrochloride
Nefazodone-d₆ (hydrochloride) is the deuterium labeled Nefazodone hydrochloride. Nefazodone hydrochloride (BMY-13754) is a potent and selective 5HT2A (Ki=5.8 nM) antagonist with moderate inhibition of 5-HT and noradrenaline uptake (IC50 of 290 and 300 nM, respectively). Nefazodone hydrochloride is a phenylpiperazine antidepressant with less alpha-adrenergic blocking activity[1][2].

HY-B1396S1

Nefazodone-d6 dihydrochloride
Nefazodone-d₆ (dihydrochloride) is deuterium labeled Nefazodone (hydrochloride). Nefazodone hydrochloride (BMY-13754) is a potent and selective 5HT2A (Ki=5.8 nM) antagonist with moderate inhibition of 5-HT and noradrenaline uptake (IC50 of 290 and 300 nM, respectively). Nefazodone hydrochloride is a phenylpiperazine antidepressant with less alpha-adrenergic blocking activity[1][2].

HY-19937S1

Saroglitazar-d4
Saroglitazar-d₄ is the deuterium-labeled Saroglitazar (HY-19937). Saroglitazar-d₄ is a novel peroxisome proliferator-activated receptor (PPAR) agonist with predominant PPARα and moderate PPARγ activity with EC₅₀ values of 0.65 pM and 3 nM in HepG2 cells, respectively.

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